Scientists hacking a smallpox-like virus into doing battle with cancer have given a new weapon to their microscopic warrior.
Researchers at Stanford University and Jennerex Biotherapeutics have tweaked the cancer-killing vaccinia virus JX-963 so that it also stimulates the body to generate cancer-fighting white blood cells. The company intends to take the virus into clinical trials based on a promising animal study.
"This is a very powerful and potent approach," said Dr. Antonio Chiocca, a professor at Ohio State University and a specialist in oncological neurosurgery, who was not involved in the study. "You can think of each of these viruses as a new drug."
Cancer-fighting viruses are the latest attempt to harness viruses' infectious powers for therapeutic treatments. Modified viruses have been used in experimental gene therapies to "fix" faulty inherited genetic code. Gene therapy has generated much hype but little clinical success. Scientists claim to have made recent progress targeting cancer cells with modded cold, herpes and smallpox viruses. These viruses infect and kill cancer cells while leaving healthy cells alone. A different Jennerex virus, JX-594, is already entering Phase II clinical trials for the treatment of liver tumors.
In a study appearing Thursday in the Journal of Clinical Investigation, the researchers report that the new JX-963 treatment resulted in the suppression of colon tumors in the rabbits on which it was tested.
"The results are very encouraging," said Dr. Stephen Thorne, a co-author of the study and professor of surgical oncology at the University of Pittsburgh. "I would envisage clinical trials starting next year."
Thorne is a Jennerex consultant.
Until now, virus therapies have had limited success targeting and killing all the cancer cells in the body, and not just some. With the new JX-963 therapy, the virus doesn't have to do the work alone -- it elicits the body's own defenses to mop up cancer cells.
The chemical that the virus secretes, granulocyte-macrophage colony-stimulating factor, or GM-CSF, is a protein that stimulates the production of white blood cells. The scientists must be careful, however, not to overstimulate the immune system so that it kills the virus before it has a chance to attack the cancer.
"You have to make sure you give the virus enough time to do its job," said Chiocca.
Paradoxically, the answer might lie in temporarily suppressing the immune system with drugs to allow the virus to spread rapidly. Then, after the virus has destroyed most of the tumor, GM-CSF stimulates an elevated immune system response.
The obvious risk of using viruses to attack cancer cells is that the virus might mutate into a deadly form. Since a death in a clinical trial in 1999, gene-therapy research has been on the back burner. Similar problems in the field of cancer-killing viruses could halt research.
Chiocca downplayed the risk from viruses that target humans, like the one used by the Stanford researchers. He said that most people already have been exposed to the smallpox, cold and herpes vaccines, so our immune systems are unlikely to be compromised by any of their forms.
However, there are more risks when researchers use viruses that attack other species. There are a small number of preclinical trials using viruses that don’t target humans, Chiocca said.
"You worry about injecting a bird virus into humans, which could potentially become adapted to the human population and create a supervirus," he said.
Posts
No comments:
Post a Comment